Good to note, That lowers possibilitys to: 1. something you did after settings wise e.g. DPI change, conflict software e.g. Realtek audio drive + nvidia HD driver Which yes still messes with usb ports,. 2. Conflict with old hardware (hardware/kernal/driver) 3. The mouse lift off not set correctly which literally causes this issue. What hardware e.g. Motherboard, Cpu, Gpu, Mouse & keyboard brand & product?